Chronic inflammatory responses involve a vast array of mechanistically unrelated, complex biological processes triggered by multiple injurious stimuli. Such processes include the production and regulated secretion of soluble mediators, the directional migration of leukocytes and other cells to the site of lesions, the onset and maintenance of defined genetic programs of differentiation and death in inflammatory cells and the tissue damage, remodeling and repair processes, just to name a few. Albeit the above processes are spatially and temporally interconnected, and the global understanding of chronic inflammation will entail the definition of such interconnections, the complete molecular dissection of each of the above processes requires dedicated efforts by scientists with highly diverse backgrounds and skills.
We believe that the most effective strategy to overcome barriers to progress in chronic inflammation is to promote the synergistic interaction of scientists from many disciplines to challenge the aforementioned processes using a reductionist approach. In the era of systems biology, is seems ill advised to start this large effort by investigating many unrelated, albeit individually relevant problems underlying chronic inflammatory responses. By focusing on one such process, rather than on several mechanistically unrelated ones, we hope to attain the highest degree of integration among the participating scientists, thereby maximizing the chances to strengthen scientific and technological excellence at the European level.
Based on the above assumptions, we decided to gather a large group of scientists, with outstanding records of research accomplishments, to focus this proposal on achieving a thorough understanding of a key basic process in chronic inflammation, i.e. directed inflammatory cell migration towards and across injured tissues.
|EU Networks of Excellence|
|Goals and framework|
|Management and Organization|
|The Consortium Agreement|