The various initiatives are comprised of highly interactive working groups of investigators, scientists with outstanding records of accomplishments in the various subdisciplines of cell migration and individuals with proven expertise in fields often unrelated to cell migration. Each strategic initiative will be under the coordination of a Principal Investigator, who will organize and administer the charge of that Program/Facility’s activity. These individuals, in consultation with others, will establish milestones, provide annual evaluations, recommend resource allocations, and direct specific activities. The MAIN Consortium will create the networking capabilities required to maximize the interactions among its member investigators. This will be achieved mainly through the establishment of a versatile, cost-effective video-conferencing system allowing continuous exchange of ideas, data and general information. This system will lay the ground for a durable integration of the research, training and educational activities developed by the Consortium. The video conferencing system utilized by the consortium is based on the Marratech software platform (http://www.marratech.com), which uses a standard H323 protocol. Since the client can be freely downloaded, authorized non-Consortium member can potentially attend MAIN videoconferences and virtual meeting rooms using standard audiovisual setups and the Marratech platform on their personal computers.