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Main-Noe Students Meeting - May 17-20th 2008, Certosa di Pontignano, Italy

MAIN Annual Conference, October 2007

MAIN LIC's Meeting, 9th March, 2007

MAIN Students' Meeting, 19th-22nd May, 2007

SEMM Workshop on Cell Migration: From Molecules to Organisms and Diseases

MAIN Science News: Paper published on "A novel protein on cells of the blood vessel w

 
 
Research > Programs > Target Identification Program (TIP)
.: Target Identification Program (TIP) :.

In response to soluble and bound signals, migrating cells become polarized and extend protrusions in the direction of migration.  These protrusions become fixed when stable adhesions form at their leading edge.  The cell body moves into the protrusion using the stable adhesions as traction points.  Adhesions release at the rear of the cell and the tail (uropod) retracts. Within the inflammatory milieu, directed cell migration and tissue infiltration are coordinated and regulated by numerous extracellular cues, intracellular signaling pathways, and dynamic cellular systems including microtubule and vesicular movements. Cells migrate in a three dimensional space. Regulated interactions with other cells and with extracellular matrix proteins are not only functional to cross anatomical barriers but also impact on the activation, differentiation and survival of the migrating inflammatory cells. The research projects carried out by the MAIN Consortium will tackle all of the individual processes impacting on inflammatory cell migration and the pathways/networks therein involved. These will include the following:

1. pathways/networks involved in sensing the extracellular cues

2. pathways/networks affecting polarity and directionality

3. pathways/networks affecting adhesion receptor dynamics

4. pathways/networks affecting contraction and motility

5. pathways/networks affecting diapedesis and invasiveness

5. pathways/networks affecting residency of inflammatory cells at the site of lesions

Pathways/networks involved in sensing the extracellular cues I: chemokines and their receptors
Pathways/networks involved in sensing the extracellular cues II: novel receptors and ligands
Pathways/networks affecting polarity and directionality I: membrane dynamics
Pathways/networks affecting polarity and directionality II: lipid second messengers
Pathways/networks affecting adhesion receptor dynamics in migrating cells
Pathways/networks affecting contraction and motility
Pathways/networks affecting diapedesis and invasiveness
Pathways/networks affecting residency of inflammatory cells at the site of lesions