Principal Investigator: M. Zvelebil, London (UK)
The Bioinformatics Core has responsibility for organizing and disseminating information gathered by the Consortium both within and outside its boundaries. One of the central objectives of the Consortium is to concentrate and focus multiple experimental approaches on the highly integrated cellular process of cell migration. Thus, the Bioinformatics Core faces significant new challenges in collecting, organizing, and disseminating data, techniques, scientific findings and methodologies developed by the Consortium. The Consortium Bionformatics Core will join efforts with the US Cell Migration Consortium to develop a highly interactive, non-redundant bioinformatics platform that can be accessed by investigators of the two consortia. This will also be achieved by linking the two consortia's web sites.
The Bioinformatics core will assist the Consortium scientists in the analysis of complex molecular processes involved in signalling pathways that are virtually impossible to analyze by cell biological experiments alone. Furthermore, what is clearly lacking is an insight into the dynamics of these signalling pathways and their interaction with each other. Mathematical and computational modelling of these complex systems can provide the means for presenting a comprehensive and integrated view on the operation of these signalling routes.
The Bioinformatics Core will also be working to display primary and processed information on the Main Consortium Web site. For this effort, the Facility will develop ontologies for the creation and storage of various types of data, including protein sequence and functional annotation, cell preparation, gene array, proteomics, cell based and molecular assays, and microscopy. These goals will be achieved through the concerted action of the Consortium Facilities. Researchers both within and outside the Consortium will be able to query and analyze all of the data from the Consortium Web site
Computer modelling of inflammatory processes and signalling pathways provides a way to integrate results from multiple types of experiment and to make predictions of cell behaviour that can be tested experimentally, leading to further refinement of the computer model. These models allow us to predict how modifying specific interactions affects cell behaviour. This is important for designing therapeutic agents in chronic inflammation.
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